Peptide half-life and why dosing frequency varies

You will see a 'half-life' listed for every peptide in the library. Understanding what it means helps the rest of the information make sense — including why one medicine is once-weekly and another is short-acting. This is conceptual education; it is not a schedule and Aminove does not suggest one.

What half-life means

Half-life is the time it takes for the amount of a substance in your body to fall by half. After one half-life, roughly half remains; after two, a quarter; and so on. A long half-life means levels stay steadier between doses; a short one means they rise and fall quickly.

Why frequency differs

• Semaglutide has a half-life of about a week, which is why it is dosed once weekly.
• Liraglutide is shorter (about half a day), so it is a daily injection.
• Many growth-hormone-releasing peptides last only minutes to a couple of hours.
• Engineering tricks — such as the DAC modification on CJC-1295 or pegylation — are used to extend half-life.

Half-life is only one factor. Approved medicines are dosed according to their trials and labels, not simply their half-life, and the right schedule for any individual is a clinical decision.

This explains a concept; it is not a dosing schedule. Aminove never recommends how often or how much to take. Consult a licensed clinician.