PEG-MGF
Animal / preclinicalWADA prohibitedAlso known as: Mechano Growth Factor, IGF-1Ec, Pegylated MGF
Community-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.
Overview
A pegylated form of mechano growth factor, a splice variant of IGF-1 expressed in muscle after mechanical stress. Marketed for muscle repair; human evidence for the marketed claims is absent and it is WADA-prohibited.
Mechanism
MGF (IGF-1Ec) is proposed to activate satellite cells and support muscle repair after damage; pegylation is intended to extend its very short half-life.
Evidence
Thin: mechanistic and rodent data on muscle repair; no human efficacy trials for the physique claims made by sellers.
Community-reported information
Community reports vary. Anecdotal and unvalidated; general information only.
General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.
Half-life
Native MGF is minutes; pegylation extends this. Not well characterised in humans.
Storage
Refrigerate lyophilised and reconstituted; sensitive to degradation.
Commonly reported side effects
- Not well characterised in humans
- Injection-site reactions reported anecdotally
Legal status by region
- USNot FDA-approved for human use.
- AUPrescription-only; import controlled.
Legal status changes over time; verify locally before relying on this.