5-Amino-1MQ
Animal / preclinicalCommunity-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.
Overview
A small-molecule NNMT inhibitor (not strictly a peptide) from academic obesity research, where it shrank fat cells and reduced weight in diet-induced obese mice without appetite suppression. Oral and popular in metabolic stacks; human trials haven't started.
Mechanism
Inhibits nicotinamide N-methyltransferase (NNMT), raising NAD+ availability in fat tissue and shifting adipocyte metabolism in animal studies.
Evidence
Compelling rodent fat-loss data via a novel mechanism; human efficacy and safety are untested.
Community-reported information
Community reports vary. Anecdotal and unvalidated; general information only.
General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.
Half-life
Not well characterised in humans (oral use common).
Storage
Room temperature (capsule formulations).
Commonly reported side effects
- Not well characterised in humans
Legal status by region
- USNot FDA-approved; not a lawful supplement ingredient.
Legal status changes over time; verify locally before relying on this.
Citations
- NNMT inhibition researchPubMed