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MOTS-c

Animal / preclinical

Also known as: Mitochondrial ORF of the 12S rRNA-c

Metabolic / fat-lossMetabolic / longevity (claimed)

Community-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.

Overview

A mitochondrial-derived peptide studied for metabolic and exercise-mimetic effects, largely in animals. Human evidence is limited.

Mechanism

Proposed to regulate metabolic homeostasis and insulin sensitivity via AMPK pathways.

Evidence

Animal / preclinicalWhat does this mean?

Thin: promising rodent and mechanistic data; human efficacy unproven.

Community-reported information

Community reports vary. Anecdotal and unvalidated; general information only.

General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.

Half-life

Not well characterised in humans.

Storage

Refrigerate.

Commonly reported side effects

  • Not well characterised in humans

Legal status by region

  • USNot FDA-approved for human use.

Legal status changes over time; verify locally before relying on this.

Citations