Humanin
Animal / preclinicalAlso known as: HN, Mitochondrial-derived peptide
Community-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.
Overview
The first mitochondrial-derived peptide discovered, studied for protecting cells against stress-induced death, with human studies linking higher natural levels to longevity — centenarian families show elevated humanin. Supplementation itself hasn't been trialled.
Mechanism
Protects cells from stress-induced apoptosis and influences insulin sensitivity and inflammatory signalling in preclinical models.
Evidence
Solid mechanistic and rodent data plus human association studies tying levels to longevity; supplementation efficacy is untested.
Community-reported information
Community reports vary. Anecdotal and unvalidated; general information only.
General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.
Half-life
Short; not well characterised in humans.
Storage
Refrigerate solutions.
Commonly reported side effects
- Not well characterised in humans
Legal status by region
- USNot FDA-approved for human use.
Legal status changes over time; verify locally before relying on this.