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MK-677 (Ibutamoren)

Human observationalWADA prohibited

Also known as: Ibutamoren

Growth-hormone secretagoguesOral GH secretagogue (investigational)

Community-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.

Overview

An orally active ghrelin-receptor agonist that raises GH and IGF-1. Investigated in trials but not approved; popular for physique use.

Mechanism

Ghrelin-receptor agonist increasing GH and IGF-1 secretion.

Evidence

Human observationalWhat does this mean?

Human pharmacology studied; long-term efficacy/safety for physique goals unproven and it is not approved.

Community-reported information

Community reports vary. Anecdotal and unvalidated; general information only.

General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.

Half-life

~4–6 hours (oral).

Storage

Room temperature (oral formulations).

Commonly reported side effects

  • Increased appetite
  • Water retention
  • Lethargy
  • Raised blood glucose

Legal status by region

  • USNot approved; not a lawful dietary supplement ingredient.
  • AUPrescription-only; import controlled.

Legal status changes over time; verify locally before relying on this.

Citations