Argireline
Human observationalAlso known as: Acetyl Hexapeptide-8, Acetyl Hexapeptide-3
Community-reported ranges are anecdotal and not clinically validated. Evidence grade shown reflects the strength of available human data. Not a prescription. Legal status varies by country and changes over time; verify locally.
Overview
A topical cosmetic peptide marketed as a needle-free alternative to botulinum toxin for expression lines. Its support is for topical cosmetic use; it is not an injectable and effects are modest.
Mechanism
Proposed to interfere with the SNARE complex involved in neurotransmitter release, mildly reducing the muscle contractions that form expression lines when applied topically.
Evidence
Modest for topical cosmetic use in small studies; comparisons to injectable botulinum toxin overstate the effect.
Community-reported information
Topical products list their own concentrations. This is a cosmetic-use ingredient, not an injectable.
General information only, not tailored to you and not a recommendation. Some regions withhold this entirely.
Half-life
Not applicable in the usual topical use.
Storage
Store per cosmetic product guidance.
Commonly reported side effects
- Mild skin irritation (topical)
Legal status by region
- USUsed as a topical cosmetic ingredient.
- GBTopical cosmetic use common; not for injection.
Legal status changes over time; verify locally before relying on this.